Chromatin vs Chromatid: Know The Ultimate Difference

Chromatin is a genetic material located in the cell nucleus. It is composed of DNA, RNA and proteins. During cell division, chromatin condenses, transforming into chromosomes. Chromosomes replicate to form identical sister chromatids connected by a structure called the centromere. Each chromatid evolves into a chromosome in the newly created cells. The topic of chromatin vs chromatid may need to be clarified for some people. So, today I will explain it as clearly as possible.

Chromatin vs Chromatid: Know The Ultimate Difference


Chromatin is the complex of DNA and proteins residing in the cell nucleus. In its euchromatic state (relaxed DNA), it appears as a diffuse network during interphase. It is composed of histones, non-histone proteins, and DNA. Chromatin serves as the storage of genetic information. Its relaxed structure allows for gene expression and normal cellular functions. 

Chromatin undergoes dynamic changes, transitioning between euchromatin and heterochromatin states. It plays a crucial role in regulating genomic activities during various cellular processes.


Chromatids are condensed structures formed during cell division when chromatin undergoes replication and condensation. They consist of two identical sister chromatids connected by a centromere. Chromatids ensure the accurate segregation of genetic material during mitosis and meiosis. Chromatids Serve as the unit of chromosome duplication. 

Chromatids guarantee that each daughter cell receives an identical set of genetic instructions. Accurate chromatid separation is crucial for stable genes and passing on genetic info to new cells.

Chromatin vs Chromatid.

Characteristic Chromatin Chromatid
Composition: DNA, histone proteins, and other proteins. DNA and proteins (form a part of a replicated chromosome).
Appearance: Diffuse and thread-like in a non-dividing cell. Condensed and visible during cell division.
Function: Involved in gene expression and normal cell activities. Actively participates in cell division, ensuring accurate genetic distribution.
State in Cell Division: Extends during interphase (non-dividing phase). Formed when chromosomes replicate and condense during cell division.
Number in a Cell: Present in all cells with a nucleus. Temporary structure formed during cell division, not a constant presence.
Role: Active in the day-to-day functions of the cell. Facilitates the separation of genetic material during cell division.
Structure: Relatively less condensed and spread out. Comprises two identical sister chromatids connected by a centromere.

FAQ About Chromatin and Chromatid.

(1) How Many Chromatids In A Chromosomes.

Chromosomes have two chromatids. Imagine chromosomes as pairs of socks, and each sock is a chromatid. They stick together like Velcro in the middle, forming an X shape. These chromatids are essential during cell division, ensuring that each new cell gets the right genetic information

So, when a cell is ready to divide, the chromosomes split, and each chromatid goes to a different cell. This process, called mitosis, helps in growth and repair. Just like socks need to match, chromosomes make sure the new cells have the same genetic instructions as the original cell.

(2) In Which Phase Are Chromatids Pulled Apart? 

Chromatids are pulled apart during a crucial phase called anaphase. Imagine it like a magic trick where the magician splits one object into two. In cell division, anaphase is the moment when the chromosomes, each with two chromatids like a pair of connected socks, are separated. 

It's like the magician pulling the socks apart, ensuring that each new cell gets a complete set. Special fibers, like invisible strings, do the pulling, making sure the genetic information is shared correctly. This step is essential for maintaining the right number of chromosomes and ensuring that each new cell is identical. This is all about Chromatin vs Chromatid. I hope you enjoyed this article.

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